Design and fabrication of accommodating fluidic intraocular lens


31-May-2018 05:01

Age-related cataract conditions are the most common.

A cataract occurs as a result of aging or secondary to hereditary factors, trauma, inflammation, metabolic or nutritional disorders, or radiation.

An accommodating intraocular lens is provided in which a deflectable lens element is anchored to a substrate along its optical axis to define a fluid filled space. Because the imaging distance is fixed, presbyopia typically entails the need for bi-focals to facilitate near and far vision. 4,816,031 to Pfoff discloses an IOL with a hard PMMA lens separated by a single chamber from a flexible thin lens layer that uses microfluid pumps to vary a volume of fluid between the PMMA lens portion and the thin layer portion and provide accommodation. In view of the foregoing, it would be desirable to provide apparatus and methods that restore appropriate optical focusing power action to the human eye.

Fluid-filled haptics disposed in fluid communication with the space vary the fluid volume in the space responsive to forces applied by the... Apart from age-related loss of accommodation ability, such loss is innate to the placement of IOLs for the treatment of cataracts. It further would be desirable to provide methods and apparatus wherein a dynamic lens surface may be effectively manipulated by the ciliary muscular mechanisms within the eye.

design and fabrication of accommodating fluidic intraocular lens-15

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12, 2002; all of which are incorporated by reference in their entirety as if fully set forth herein. As noted above, the youthful eye has approximately 14 diopters of accommodation. Although fluid-actuated mechanisms such as described in the aforementioned patents have been investigated, commercially available accommodating lenses, such as developed by Eyeonics, Inc. Accordingly, when the ciliary muscles are relaxed, the capsule and lens are pulled about the circumference to a larger diameter, thereby flattening the lens, whereas when the ciliary muscles are contracted, the lens and capsule relax somewhat and assume a smaller diameter that approaches a more spherical shape, thereby increasing the diopter power of the lens. discloses an intraocular lens comprising a thin flexible layer sealed along its periphery to a support layer, wherein forces applied to fluid reservoirs in the haptics vary a volume of fluid between the plurality of layers to provide accommodation.An accommodating intraocular lens is provided in which a deflectable lens element is anchored to a substrate along its optical axis to define a fluid filled space. IOLs are generally single element lenses made from a suitable polymer material, such as acrylics or silicones. It still further would be desirable to provide methods and apparatus that utilize pressure applied by the accommodating muscular action to deform an optical surface of the IOL.

Fluid-filled haptics disposed in fluid communication with the space vary the fluid volume in the space responsive to forces applied by the ciliary muscles, thereby causing the periphery of the lens element to deflect relative to the substrate and changing the optical power of the intraocular optic comprising a flexible anterior element, a posterior element, an optical axis, the flexible anterior element is the most anterior aspect of the accommodating intraocular lens along the optical axis, the flexible anterior element and the posterior element at least partially defining an optic fluid chamber disposed between the flexible anterior element and the posterior element;a haptic portion peripheral to the optic and configured to deform in responsive to ciliary muscle movement, the haptic portion comprising at least one haptic fluid chamber in fluid communication with the optic fluid chamber; anda fluid disposed within the optic fluid chamber and the at least one haptic fluid chamber, wherein the fluid is adapted to be moved between the at least one haptic fluid chamber and the optic fluid chamber in response to deformation of the haptic portion, and wherein a periphery of the flexible anterior element is adapted to be displaced more than a portion of the flexible anterior element disposed along the optical axis in response to movement of the fluid. After placement, accommodation is no longer possible, although this ability is typically already lost for persons receiving an IOL. 5,443,506 to Garabet describes an accommodating fluid-filled lens wherein electrical potentials generated by contraction of the ciliary muscles cause changes in the index of refraction of fluid carried within a central optic portion. In particular, it would be desirable to provide an IOL in which muscular pressure may be applied through one or more actuators to obtain a mechanical advantage.

The ciliary muscles that support the lens and capsule therefore are believed to act in a sphincter muscular mode.